Alcohol damages DNA and increases the risk of cancer

Drinking too much alcohol not only can put in danger your root canal in Tijuana Mexico but in can cause cancer in cell cultures. Now, a new study, funded in part by Cancer Research UK and published in the journal Nature, has used mice to show how exposure to alcohol leads to permanent genetic damage.

Researchers from the Molecular Biology Laboratory of the Medical Research Council (MRC) in the United Kingdom gave dilute alcohol, chemically known as ethanol, to mice. They then used chromosomal analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical that occurs when the body processes alcohol.

They discovered that acetaldehyde can break down and damage the DNA inside the blood stem cells, which causes the reorganization of the chromosomes and the permanent alteration of the DNA sequences within these cells.

It is important to understand how DNA design is damaged within stem cells because when healthy cells become defective, they can cause cancer, according to the study.

Therefore, these new findings help to understand how alcohol consumption increases the risk of developing seven types of cancer: breast, intestine, liver, mouth, throat, esophagus and larynx.

Ketan Patel, lead author of the study and MRC scientist, notes: “Some cancers develop due to DNA damage in the stem cells, which indicates that drinking alcohol can increase this risk.”

Enzymes defending against alcohol
The study also examined how the body tries to protect itself against injuries caused by alcohol. The first line of defense is a family of enzymes called aldehyde dehydrogenases (ALDH). These enzymes break down the harmful acetaldehyde into acetate, which our cells can use as an energy source.

Around the world, millions of people, particularly those in Southeast Asia, lack these enzymes or have defective versions of them. Therefore, when they drink, acetaldehyde accumulates, which causes a flushed complexion and also makes them feel bad.

In the investigation, when mice lacking the critical ALDH enzyme (ALDH2) were given alcohol, four times more DNA damage occurred in their cells compared to mice with the fully functional ALDH2 enzyme.

The second line of defense used by cells is a variety of DNA repair systems that, most of the time, allow them to repair and reverse different types of injuries. But they do not always work and some people carry mutations, which means that their cells can not carry out these repairs effectively.

Our study emphasizes that not processing alcohol effectively can lead to an increased risk of problems related to alcohol and, therefore, certain cancers. But it is important to remember that systems of alcohol elimination and DNA repair are not perfect and alcohol can cause cancer in different ways, even in people whose defense mechanisms are intact.

This research highlights the damage that alcohol can cause in our cells, some people find it harder than a simple hangover. We know that alcohol contributes to more than 12,000 cases of cancer in the UK each year, so it’s a good idea to think about reducing the amount you drink.

Information You Need Before Get Dental Implants

If have missing one or more teeth people may have recommend you to put you a dental bridge, and you may be curious what exactly a dental bridge is?. Well if you are the type of person that doesn’t like to go to the dentist without before make a little research, here we can help you with some information that can help you to understand what the dentist would say to you.
Something that you must care is what kind of materials your dentist is going to use of your dental bridges in Tijuana. Bridges are manufactured from metal, ceramics (porcelain) or a mixture of the two. Ceramics frequently are bonded to a metal alloy. Some dentist do Zirconia bridge which is not grey, some even have Gold Bridges, also the price of your bridges can vary depending of the material you choose. Your dentist in Mexico will talk about the stuff which might be best for you and the mouth area with you. You may want to know that your bridges take some time to be done; the average time is around seven days even though if you cannot wait seven days for your bridge some dentists may charge you an additional cost to make your bridge faster.
Taking care of Your Bridge. Do not invest in something you will not take care of. Dental bridges need a very consistent cleaning routine or else you bridge can fail. This happened whether the jawbone or the support teeth is damaged by dental disease. Follow these suggestions for great oral health: Brush your teeth two times a day and floss or use other between-the-teeth cleaner once a day. Brushing and cleaning involving the teeth helps remove plaque, a sticky film of bacteria that is always forming on the teeth. Consistently clean between your teeth and beneath the bridge. You will find many kinds of brushes that are small or flosses, picks —ask your dentist what kind will work well with your bridge. See your dentist regularly for examinations and professional cleanings. Eat a healthful diet.